Journal of Liver Cancer

1 "COX-2 inhibitor"

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Case Report

A Case of Complete Regression of Hepatocellular Carcinoma during COX-2 Inhibitor Administration: Hae Jung Song, Yun Soo Kim, Chang Hee Han, Jae Young Jang, Jung Hoon Kim, Young Koog Cheon, Young Seok Kim, Jong Ho Moon, Young Deok Cho, Chan Sup Shim, Boo Sung Kim; Journal of the Korean Liver Cancer Study Group. 2006;6(1):65-69. Published online June 30, 2006

Abstract PDF: Overexpression of cyclooxygenase-2 (COX-2) has been associated with hepatocarcinogenesis. Inhibitors of COX-2 have proapoptotic and antiproliferative effects on malignant tumors and inhibit their invasion to surrounding tissues. We report a case of complete regression of advanced HCC during COX-2 inhibitor administration. An eighty-year-old female was diagnosed as advanced hepatocellular carcinoma (HCC) which was associated with HCV infection. She received COX-2 inhibitor for 3 months due to degenerative arthritis of both knees. Tumor enhancement on arterial phase was completely disappeared without specific treatment for the HCC, and the size of mass markedly decreased on follow-up CT scan.

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