Journal of Liver Cancer

2 "Bile duct thrombi"

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Review Article

Hepatocellular Carcinoma Invading Bile Duct: Geum Youn Gwak; Journal of the Korean Liver Cancer Study Group. 2008;8(1):1-7. Published online June 30, 2008

Abstract PDF: Although invasion of portal veins and hepatic veins is common in hepatocellular carcinoma (HCC), macroscopic bile duct invasion is rare. Bile duct thrombi have been identified in 0.5% to 9% of HCC patients. In general, these patients have a worse clinical course and shorter survival than patients without bile duct thrombi, probably attributable to the low resectability rate secondary to poor functional reserve caused by obstructive jaundice and cholangitis, and combined major vascular invasion. However, a few data demonstrated that an aggressive operative approach after appropriate preoperative management offered a better chance of long-term survival in some patients with HCC with bile duct thrombi. Herein, we describe some cases of HCC with bile duct thrombi and summarize clinical features and treatment outcomes on the basis of the literatures published to date.

Case Report

A Case of Hepatocellular Carcinoma With Bile Duct Thrombi Presenting Obstructive Jaundice: Su Rin Shin, Geum-Youn Gwak, Cheol Keun Park, Won Jae Lee, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Won Paik, Byung Chul Yoo; Journal of the Korean Liver Cancer Study Group. 2008;8(1):47-50. Published online June 30, 2008

Abstract PDF: Although invasion into blood vessels, particularly the portal vein, is a common feature of hepatocellular carcinoma (HCC), intrabile duct invasion has been considered rare. HCC with bile duct thrombi is occasionally misdiagnosed as biliary carcinoma or stone, and tends to have a worse clinical course than HCC without bile duct thrombi, probably attributable to the low resectability rate secondary to poor functional reserve caused by obstructive jaundice, and combined major vascular invasion. However, a few data demonstrated that obstructive jaundice aroused an early detection of HCC, leading to a better survival. Herein, we describe a case of HCC with bile duct thrombi, which was diagnosed at an early stage with obstructive jaundice and had a favorable course after surgical resection.

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