Journal of Liver Cancer

Original Article

The effect of nucleos(t)ide analogues on clinical outcomes of patients treated with transarterial chemoembolization and radiofrequency ablation for hepatitis B virus-related hepatocellular carcinoma: Jae Min Park, Won Hyeok Choe, Jeong Han Kim, So Young Kwon, Byung Chul Yoo; J Liver Cancer. 2021;21(2):155-162. Published online September 30, 2021; DOI: https://doi.org/10.17998/jlc.2021.09.22

6,249 Views
105 Downloads
3 Citations

Background/Aims
Because hepatitis B virus (HBV) replication has been known to play an important role in cancer recurrence after curative treatment of HBV-related hepatocellular carcinoma (HCC), we examined whether treatment based on nucleos(t)ide analogues (NAs) might decrease the recurrence rate and improve patient survival.
Methods
The retrospective cohort study enrolled 73 patients with chronic hepatitis B who were treated with transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) with curative intent for HCC. Among those, 30 and 43 patients were treated with tenofovir disoproxil fumarate (TDF) and entecavir (ETV), respectively.
Results
Of the 73 patients, 51 experienced HCC recurrence, and 14 patients were dead during a follow-up of 73±34 months. Multivariate analyses showed that tumor size (hazard ratio [HR], 1.590; 95% confidence-interval [CI], 1.106-2.285; P=0.012) and Child-Pugh class B (vs. class A/non cirrhosis; HR, 5.794; 95% CI, 2.311-14.523; P=0.001) was significantly associated with HCC recurrence, and Child-Pugh class B (HR, 7.357; 95% CI, 2.100-25.777; P=0.002) was an independent unfavorable prognostic factor for survival. During NAs therapy, TDF was superior to ETV for complete viral response at 1 year after the date of combination of TACE and RFA (P=0.016). However, the risks of HCC recurrence and survival were not significantly different between those treated with TDF versus ETV.
Conclusions
TDF was superior to ETV for achieving complete viral response. However, the recurrence and mortality after TACE and RFA for HBV-related HCC were not significantly different between patients treated with TDF versus ETV.

Citations

Citations to this article as recorded by

Enhanced prognosis of HCC patients undergoing radical treatments with tenofovir versus entecavir: A meta-analysis based on propensity score matching studies
Qingyan Kong, Mengshi Yi, Fei Teng, Zheyu Chen
Asian Journal of Surgery.2024; 47(1): 55. CrossRef
Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis
Hui Liu, Cheng-Long Han, Bao-Wen Tian, Zi-Niu Ding, Ya-Fei Yang, Yun-Long Ma, Chun-Cheng Yang, Guang-Xiao Meng, Jun-Shuai Xue, Dong-Xu Wang, Zhao-Ru Dong, Zhi-Qiang Chen, Jian-Guo Hong, Tao Li
Expert Review of Gastroenterology & Hepatology.2023; 17(6): 623. CrossRef
A nationwide study on the current treatment status and natural prognosis of hepatocellular carcinoma in elderly
Jeong-Ju Yoo, Jayoun Lee, Gi Hong Choi, Min Woo Lee, Dong Ah Park
Scientific Reports.2023;[Epub] CrossRef

Case Report

Recurrent Coronary Artery Vasospasm in a Patient with Hepatocellular Carcinoma Treated with Sorafenib: a Case Report and Literature Review: Dae Hyun Lim, Jai Hoon Yoon, Dae Won Jun, Oh Young Lee, Byung Chul Yoon, Hang Rak Lee, Kyung Soo Kim, Ho Soon Choi; J Liver Cancer. 2020;20(1):67-71. Published online March 31, 2020; DOI: https://doi.org/10.17998/jlc.20.1.67

6,201 Views
96 Downloads

Abstract PDF: Tyrosine kinase inhibitors are widely used as targeted treatments for various malignancies. Sorafenib is an orally active tyrosine kinase inhibitor that blocks the signaling pathways of several growth factors. Its use is approved for various malignancies such as unresectable hepatocellular carcinoma, renal cell carcinoma, and gastrointestinal stromal tumors. Several adverse effects have been reported in the literature; however, cardiotoxicity is rare. We present a case of recurrent coronary vasospasm caused by short-term administration (5 days) of sorafenib. Since it caused refractory ischemia after re-administration, we had no choice but to stop the treatment.

Original Article

Cirrhosis in Surgically Resected Hepatitis C-Associated Hepatocellular Carcinoma in a Hepatitis B Endemic Area: Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Jae-Won Joh, Seung Woon Paik, Byung Chul Yoo, Cheol Keun Park; J Liver Cancer. 2014;14(2):108-114. Published online September 30, 2014; DOI: https://doi.org/10.17998/jlc.14.2.108

1,468 Views
4 Downloads

Abstract PDF: Background/Aims
Cirrhosis has generally been considered a prerequisite for hepatitis C virus (HCV)-infected livers to develop hepatocellular carcinoma (HCC), but HCCs that arise in absence of cirrhosis has been reported. We assessed the prevalence and significance of cirrhosis in HCV-related HCC patients who underwent surgical resection.
Methods
A total of 78 HCC patients (65 male [83.3%]; mean age, 64.2 ± 8.6 years) were evaluated for the presence of cirrhosis. Cirrhosis was assessed based on histology, aspartate aminotransferase-to-platelet ratio index (APRI) as well as clinical criteria, such as ascites, varices, thrombocytopenia, splenomegaly, and radiographic configuration of cirrhosis.
Results
Based on histology, cirrhosis, septal fibrosis, periportal fibrosis and no fibrosis was noticed in 33.3%, 60.3%, 5.1% and 1.3% of patients, respectively. The clinical criteria of cirrhosis were present in 76.9% of patients. APRI > 1.0 was seen in 47.4% of patients. There was no evidence of cirrhosis in 18 patients (23.1%), either by histology or clinically. Cirrhosis by histology was an independent factor for overall survival [hazard ratio: 3.87 (95% CI: 1.24 – 12.00), P=0.019].
Conclusions
Quite proportion of HCC patients had no evidence of cirrhosis, either by histology or clinically. Careful follow-up for HCC may be necessary even for non-cirrhotic HCVinfected Korean patients. (J Liver Cancer 2014;14:108-114)

Case Reports

A Case of Hepatocellular Carcinoma With Bile Duct Thrombi Presenting Obstructive Jaundice: Su Rin Shin, Geum-Youn Gwak, Cheol Keun Park, Won Jae Lee, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Won Paik, Byung Chul Yoo; Journal of the Korean Liver Cancer Study Group. 2008;8(1):47-50. Published online June 30, 2008

997 Views
5 Downloads

Abstract PDF: Although invasion into blood vessels, particularly the portal vein, is a common feature of hepatocellular carcinoma (HCC), intrabile duct invasion has been considered rare. HCC with bile duct thrombi is occasionally misdiagnosed as biliary carcinoma or stone, and tends to have a worse clinical course than HCC without bile duct thrombi, probably attributable to the low resectability rate secondary to poor functional reserve caused by obstructive jaundice, and combined major vascular invasion. However, a few data demonstrated that obstructive jaundice aroused an early detection of HCC, leading to a better survival. Herein, we describe a case of HCC with bile duct thrombi, which was diagnosed at an early stage with obstructive jaundice and had a favorable course after surgical resection.

A Case of Combined Hepatocellular-Cholangiocarcinoma Mimicking Focal Nodular Hyperplasia: Dong Hyun Shin, Kwang Cheol Koh, Geum Youn Gwak, Dong Il Choi, Cheol Keun Park, Moon Seok Choi, Joon Hyoek Lee, Seung Woon Paik, Byung Chul Yoo; Journal of the Korean Liver Cancer Study Group. 2007;7(1):55-58. Published online June 30, 2007

995 Views
5 Downloads

Abstract PDF: Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is an uncommon form of primary liver cancer having features of both hepatocellular and billiary epithelial differentiation. We report a case of cHCC-CC in a patient who was serologically positive for hepatitis B virus. A 39-year-old male was diagnosed by ultrasonography with an asymptomatic tumor in the left lobe of the liver. Based on radiologic and serologic findings of elevated serum alpha-fetoprotein level, a preoperative diagnosis of hepatocellular carcinoma was made, but differential diagnosis included focal nodular hyperplasia, because tumor was enhanced in delayed phase in Godolinium MRI scan. A final diagnosis of cHCC-CC was made after operation.

A Case of Focal Nodular Hyperplasia: Beom Jin Kim, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Won Jae Lee, Cheol Keun Park; Journal of the Korean Liver Cancer Study Group. 2003;3(1):61-64. Published online July 31, 2003

1,101 Views
10 Downloads

Abstract PDF: Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion characterized by nodular hyperplasia of hepatic parenchyma around a central stellate area of fibrosis associated with an anomalous artery. The histological feature of FNH is dominated by a progressive fibrotic process. In the present report, we described a 2.2×2.1 cm sized asymptomatic lesion of FNH observed in a 47-year-old woman with hepatitis B healthy carrier. This lesion was disclosed by various imaging procedures. Under the clinical impression of hepatocellular carcinoma a right. lobe subsegmentectomy was performed. The mass was firm and showed yellow-brownish color and septal fibrosis. It was accompanied with marginal ductal proliferation. These results were consistent with the typical observations in FNH. It also showed small stellate scar with radiating thin fibrous band and formation of small parenchymal nodules. We report a case of FNH of the liver difficult to differentiate hepatocellular carcinoma.

A Case of Mixed Hepatocellular and Cholangiocarcinoma: Jae Hyuk Do, Joong-Won Park, Hyung Joon Kim, Eon Seob Park, Jong Beom Lee, Byung Chul Yoo, Sill Moo Park; Journal of the Korean Liver Cancer Study Group. 2002;2(1):83-87. Published online July 31, 2002

988 Views
3 Downloads

Abstract PDF: Mixed hepatocellular and cholangiocarcinoma (HCC-CC) is an uncommon form of primary liver cancer. Definition of HCC-CC is both hepatocellular carcinoma and cholangiocarcinoma in the same tumor or in the same liver. We had experienced a case of HCC-CC. A 49 year-old male, who had social drinking history, admitted due to abdominal distension for about 4 days. Physical findings revealed that he had jaundice and ascites. The serum level of total bilirubin, direct bilirubin, AST, ALT, ALP and LDH were elevated. And serum levels of AFP and CEA were normal. But CA 19-9 level was elevated. Hepatitis B surface antibody was positive and anti-HCV antibody was negative. The level of SAAG was 1.4. The US and CT scans revealed heterogeneous echoic and hypodense multifocal mass like lesions were noted on the S6, S7, S8 and S5. And about 3 cm-sized hperechoic ovoid mass lesion was detected at S6. This lesions was not enhanced after contrast injection in CT scan. The IVC and hepatic veins were stenotic and right portal vein was obstructed due to thrombosis. But main portal vein, left portal vein and hepatic arteries were intact. We performed US　guide gun biopsy at this mass-like lesion in S6 and diagnosed as mixed hepatocellular and cholangiocarcinoma.

A Case of Hepatocellular Carcinoma: Curative Resection after Repeated Transcatheter Arterial Chemoembolization: Jae Hyuk Do, Joon Won Park, Hyung Joon Kim, Hyung Jin Shim, Byung Chul Yoo, Sung Il Park, Sil Moo Park; Journal of the Korean Liver Cancer Study Group. 2001;1(1):110-113. Published online June 30, 2001

7,679 Views
2 Downloads

Abstract PDF: A 57 year-old-male, who had a 40-year history of chronic alcohol dirnking, was referred to general weakness and jaundice for 1 month. Physical findings revealed that he had jaundice and spider angioma on anterior chest wall. The serum chemistries showed the total bilirubin 9.3 mg/dL and direct bilirubin level 6.1 mg/dL. The serum level of AST/ALT/AP was 130/192/494 IU/L. And the serum level of AFP was 18225.7 ng/ml. abdomen CT scan revealed the huge ill-defined hypodense mass was involving segment 2 and 3. The main portal vein and left portal vein were involved by this mass. Abdominal ultrasonography (US) showed huge echogenic mass in hilar portion of bile duct and tumor thrombosis in main and left portal vein. ERCP showed intraluminal-filling defect in CHD and complete obstruction of left IHD. We had a diagnosis this mass as hepatocellular carcinoma by US guided gun biopsy. Transcatheter arterial chemoembolization (TACE) was selected as the treatment due to TNM stage Ⅳa. After three times repeated TACE tumor decreased in size, regression of left portal vein invasion and normalization of jaundice, as a result, curative left lobectomy could be performed.

First
Prev
Page of 1
Next
Last

Search