Journal of Liver Cancer

High Precision Radiotherapy of Hepatocellular Carcinoma: Jinsil Seong; Journal of the Korean Liver Cancer Study Group. 2005;5(1):1-6. Published online June 30, 2005

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How to Prevent Post Operative Hepatic Failure after Hepatic Resection: Jinsub Choi; Journal of the Korean Liver Cancer Study Group. 2005;5(1):7-11. Published online June 30, 2005

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Complications after Radiofrequency Thermal Ablation of Hepatocellular Carcinoma: Hyunchul Rhim; Journal of the Korean Liver Cancer Study Group. 2005;5(1):12-17. Published online June 30, 2005

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Abstract PDF: Radiofrequency (RF) thermal ablation has been accepted as a promising technique for treating unresectable liver tumors. However, any interventional procedure should only be performed with minimal morbidity and mortality. Recently three separate multicenter surveys have shown an acceptable morbidity and mortality for a minimally invasive technique. The mortality ranged from 0.1-0.5%, the major complication rate from 2.2-3.1% and minor complication rate from 5-8.9%. The most common causes of death were sepsis and hepatic failure, and the most common major complications were intra-peritoneal bleeding, hepatic abscess, bile duct injury, hepatic decompensation and grounding pad burns. Minor complications and side effects were more common than major complications, but most of them were transient and self-limiting. The operator must understand the broad spectrum of complications after RF ablation as well as the strategies to minimize and manage appropriately

Chemotherapy for Hepatocellular Carcinoma: Sung Won Cho, Jae Youn Cheong; Journal of the Korean Liver Cancer Study Group. 2005;5(1):18-21. Published online June 30, 2005

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Curative Resection of Advanced Hepatocellular Carcinoma (TNM stage IVa) after Concurrent Chemo-Radiation Therapy: A Case Report: DY Kim, KH Han, SH Ahn, CM Moon, KK Kim, CY Chon, YM Moon, KS Kim, JS Sung, YN Park; Journal of the Korean Liver Cancer Study Group. 2005;5(1):22-26. Published online June 30, 2005

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Abstract PDF: Hepatocellular carcinoma (HCC) with portal vein thrombosis is a difficult form of HCC to treat. Therefore, no specific treatment mordality has been absent. Here, we present a patient diagnosed as hepatocellular carcinoma with right portal vein thrombosis (stage IVa). The patient had been treated with concurrent chemo-radiation therapy (CCRT) for five weeks. After CCRR, tumor size was markedly decreased. Two courses of additional transcatheter arterial chemoembolization (TACE) and five courses of intraarterial 5-fluorouracil (5-FU)/cisplatin infusion were performed. Follow-up computerized tomography (CT) scan showed about 2cm-sized nodular lesion at lateral margin of right hepatic lobe. On angiography, it was shown that both the mass and intestine were commonly supplied by omental artery. For the treatment of the mass, right hepatic lobectomy was undertaken.

A Case of Intensity Modulated Radiotherapy in Hepatocellular Carcinoma: Su Jung Shim, Jinsil Seong; Journal of the Korean Liver Cancer Study Group. 2005;5(1):27-29. Published online June 30, 2005

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Abstract PDF: Intensity modulated radiotherapy (IMRT) is the recent advanced radiotherapy technique that could perform the modulation of radiation intensity for the various targets. A 65-year-old female with chronic hepatitis C virus (HCV) infection (for more than 10 years) was incidentally found to a 3 cm hepatocellular carcinoma (HCC) in the segment 8 of liver. We report a case of HCC after transcatheter arterial chemoembolization (TACE) that successfully treated with IMRT.

Four Cases of Hepatocellular Carcinoma Treated with CyberKnife: So Yeon Lee, Si Hyun Bae, Min Su Kim, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Joon Yeol Han, Kyu Won Chung, Young Nam Kang, Byung Ock Choi, Ihl Bohng Choi, Boo Sung Kim; Journal of the Korean Liver Cancer Study Group. 2005;5(1):30-36. Published online June 30, 2005

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Abstract PDF: CyberKnife, a new FSRT (Fractionated Stereotactic Radiotherapy) system which utilize a novel, light-weight, and high-energy radiation source, was introduced as a newly-developed therapeutic modality for solid tumors. In this report, we present 4 cases of hepatocellular carcinoma treated with CyberKnife. - 1. Single nodular hepatocellular carcinoma (stage II), 2. Advanced hepatocellular carcinoma with portal vein invasion (stage IVa), 3. Advanced hepatocellular carcinoma with metastatic intraabdominal lymphadenopathy (stage IVa), 4. Advanced hepatocellular carcinoma with right atrium invasion (stage IVb). Two patients showed complete response, and the other two patients showed partial response without major complications. After the treatment, they are in good general condition under observation at out-patient clinic. The present cases show that CyberKnife can give a chance of cure for small hepatocellular carcinoma and may also be used as an additional therapeutic modality for advanced hepatocellular carcinoma.

Report of Two Patients Treated with 3-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma: Kyung Woo Park, Joong-Won Park, Sang-Hyung Cho, Young Il Kim, Seong Hoon Kim, Hong Suk Park, Woo Jin Lee, Sang Jae Park, Dae Young Kim, Eun Kyoung Hong, Chang-Min Kim; Journal of the Korean Liver Cancer Study Group. 2005;5(1):37-41. Published online June 30, 2005

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Abstract PDF: Recently, radiotherapy is considered as one of the palliative treatment modalities for patients with hepatocellular carcinoma. In the adevent of 3-dimensional conformal radiotherapy, liver can be treated with high dose radiotherapy without increment of complication. We report two cases of hepatocellular carcinoma with main portal vein thrombosis, who were treated with 3D-CRT and showed promising outcome.

A Case of Hepatic Failure Triggered by Acute Renal Failure after Transarterial Chemoembolization for Hepatocellular Carcinoma: Woo Jin Chung, Jae Seok Hwang, Yoon Seok Hong, Jung Min Lee, Byung Kuk Jang, Kyung Sik Park, Kwang Bum Cho, Sung Hun Ahn, Jung Hyeok Kwon, Young Hwan Kim, Jin Su Choi; Journal of the Korean Liver Cancer Study Group. 2005;5(1):42-44. Published online June 30, 2005

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Abstract PDF: A 72-years-old man who had HCV antibody underwent transarterial chemoembolization due to hepatocellular carcinoma. Before transarterial chemoembolization, his creatinin level was 1.7 mg/dl. After 2 days later, acute renal failure was developed and subsequently esophageal variceal bleeding and hepatorenal syndrome were developed. After 1month later, he was dead due to hepatic failure. We report a case of hepatic failure triggered by acute renal failure which was doubted by contrast media.

Hepatic Failure after Chemotherapy in Patient with HBV-related HCC: Report of 1 Case: Sang Kyun Yu, Hwang Rae Chun, Chang Won Baeck, Soon Ho Um; Journal of the Korean Liver Cancer Study Group. 2005;5(1):45-48. Published online June 30, 2005

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Abstract PDF: Hepatitis B virus (HBV) reactivation is a well described complication in cancer patitient who receive cytotoxic chemotherapy and may result in varying degree of liver damage. Liver damage due to HBV exacerbation is a 2-stage process. The initial stage occurs during intense cytotoxic therapy and is characterized by enhancing viral replication, as reflected by increases in serum levels of HBV DNA, HBeAg, which presumably result in widespread infection of hepatocytes. The second stage is related to restoration of immune function following withdrawl of cytotoxic therapy, which cause rapid immune-mediated destruction of infected hepatocyte. Clinically, this may lead to hepatitis, hepatic failure, and even death. We report a case of hepatic failure after chemotherapy in patient with HBV-related hepatocelluar carcinoma.

A Case of Liver Failure after Liver Resection for Treatment of Hepatocellular Carcinoma: Kyung Woo Park, Sang Jae Park, Young Il Kim, Seong Hoon Kim, Hong Suk Park, Woo Jin Lee, Dae Young Kim, Eun Kyoung Hong, Joong-Won Park, Chang-Min Kim; Journal of the Korean Liver Cancer Study Group. 2005;5(1):49-51. Published online June 30, 2005

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Abstract PDF: Liver resection is an important curable treatment modality for patient with early hepatocelluar carcinoma (HCC) with good underlying liver function. Recently, mortality after liver resection for HCC became low, however morbidity is still significantly high. Liver failure is the most serious complication of liver resection. We report a
case
of liver failure following liver resection for hepatocellular carcinoma who recovered spontaneously.

Two Cases of Acute Hepatic Decompensation after Concurrent Chemoradiotherapy in Patients with Advanced Hepatocellular Carcinoma: Myoung Hwan Kim, Sang Hoon Ahn, Yong Han Paik, Kwan Sik Lee, Chae Yoon Chon, Young Myoung Moon, Jinsil Seong, Kwang Hyub Han; Journal of the Korean Liver Cancer Study Group. 2005;5(1):52-56. Published online June 30, 2005

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Abstract PDF: Advanced hepatocellular carcinoma with portal vein thrombosis has a poor prognosis. Concurrent chemoradiation (CCRT) therapy achieved favorable results in advanced hepatocellular carcinoma with portal vein thrombosis and can be considered as a treatment option for the management of advanced hepatocellular carcinoma.2 But, exacerbation of liver function during concurrent chemoradiotherapy is a critical complication in patients with hepatitis B virus (HBV) related HCC. Reactivation of HBV replication is a well-known complication in cancer patients receiving chemotherapy. We report two cases with acute exacerbation of liver function. The one
result
ed in hepatic decompensation after CCRT probably due to HCC progression and/or chemoradiotherapy and the other is due to reactivation of HBV replication after CCRT, who recovered after lamivudine and corticosteroid therapy.

A Case of Ileus Arising after Radiofrequency Ablation for the Treatment of Hepatocellular Carcinoma: Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Young Jun Lee, Jae Young Byun; Journal of the Korean Liver Cancer Study Group. 2005;5(1):57-59. Published online June 30, 2005

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Abstract PDF: Radiofrequency ablation (RFA) was introduced as a local therapeutic approach for a variety of malignant diseases. This modality has been reported to be one of the most feasible image-guided techniques, which can even cure a small cancer with one session of ablation. Although this technique is generally considered safe, adverse events attributable to the procedure have often been reported. Recently, we experienced a case of ileus arising acutely after the completion of RFA in the treatment of a small HCC. Until now, reports on the occurrence of ileus after RFA are almost lacking. In this rare case, we discussed the possible cause of the adverse event with a brief review of relevant literatures.

A Case of Intraperitoneal Hemorrhage after Radiofrequency Ablation: Yeon Seok Seo, Soon-Ho Um, Yun Hwan Kim; Journal of the Korean Liver Cancer Study Group. 2005;5(1):60-67. Published online June 30, 2005

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Abstract PDF: A case of intraperitoneal hemorrhage after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) was presented. Fifty-six years old male was admitted in our hospital to evaluate two hepatic masses found on ultrasonographic screening examination. With 3-phase abdominal CT, the masses were diagnosed as HCC. For the treatment, TACE was performed, but therapeutic response was inadequate, so RFA was performed. On 2nd day after RFA, he complained dizziness with hemoglobin level being lowered. Abdominal distension was aggravated, and on diagnostic paracentesis, the bloody ascites were noted. Urgent celiac angiogram was performed, but any definite bleeding focus was not found. With conservative management, his condition improved without a further decrease in following hemoglobin level. He was discharged on 20th day after RFA.

A Case of Needle Tract Implantation of Hepatocellular Carcinoma after Radiofrequency Ablation: Nak So Chung, Cheul Hee Park, So Young Kwon, Young Nam Kim, Oh Sang Kwon, Sun Suk Kim, Duck Joo Choi, Ju Hyun Kim; Journal of the Korean Liver Cancer Study Group. 2005;5(1):68-70. Published online June 30, 2005

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Abstract PDF: The tumor seeding after local ablation therapy is a rare complication in hepatocellular carcinoma. We report a
case
of needle tract implantation of hepatocellular carcinoma following radiofrequency ablation therapy manifested as a omental mass. The metastatic mass was surgically removed.

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