Abstract

Combined hepatocellular carcinoma and cholangiocarcinoma (CHC) is a rare form of primary liver cancer having features of both hepatocelluar and biliary epithelial differentiation and is related to cirrhosis. Recently, a 64-oldmale who was admitted to our hospital for evaulation of hepatic mass which was detected on ultrasonography. He had no underlying cirrhosis. Based on serologic findings of high alpha-fetoprotein(AFP) level, a preoperative diagnosis of hepatocellular carcinoma was made. A right lobectomy was done. On histologic examination, the resected tumor was shown to consist of two different tissues. On immunohistochemistry, the tumor is postitive for both anti-hepatocyte, CK-7 and CK-19. Finally we confirm combined hepatocellular carcinoma and cholangiocarcinoma (CHC).

• Keywords: Combined hepatocellular carcinoma and cholangiocarcinoma;Alpha fetoprotein (AFP)